The Relationship Between Cervical Cancer Severity and miRNA-205 Expression in Bali

Cervical cancer is the one of leading cause death for women worldwide. It occurs due to infection with human papilloma virus (HPV) which attacks cervix in female reproductive organs. The detecting cervical method by using pap smears and liquid based cytology (LBC) vaccinations. However, both methods are limited quickly accurately. This study aims find potential biomarkers that will be used detect development cancer. Large-scale studies have shown microRNA-205 (miRNA) regulation has a very important role various types including extraction synthesis cDNA from 26 preparations paraffin blocks were measured quantitative real time PCR evaluate expression miRNA-205 as biomarker samples. Statistical results showed there was significant difference relatively higher patients (p<0.05) miRNA-205. In addition, increased associated an increase severity We conclude candidate molecular biomarker.